Across TCGA pan-cancer cohorts, SPN mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPN data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SPN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPN expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD and PDAC are the cancer types where SPN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.831	0.487	.022	4	view →
PDAC	OS	Tertile	III,IV	0.500	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SPN tumor-vs-normal RNA expression · all SPN data types