Across TCGA patient cohorts, SPN RNA expression is significantly associated with the protein abundance of many other proteins, with 21,500 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPN-associated proteins across cancer lineages are RAC2, RASAL3_S72, and MYO1F. Each is linked with SPN in more than 9 cancer types. Because this analysis shows association rather than direction, both SPN-to-partner and partner-to-SPN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPN→partner) and Y-score (partner→SPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RAC2 →	+0.778	+0.749	<.001	<.001	3	10
LSCC	RASAL3_S72 →	+0.819	+0.899	<.001	<.001	3	10
GBM	MYO1F →	+0.514	+0.493	<.001	<.001	3	10
GBM	MYO1G →	+0.659	+0.674	<.001	<.001	3	10
OV	BTK →	+0.684	+1.030	.001	<.001	3	10
HNSC	CD4 →	+0.766	+1.158	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,500 associations by consensus.

Exploration

SPN survival (RNA) · tumor vs normal (RNA) · all SPN data types