Across TCGA patient cohorts, SPN protein abundance is significantly associated with the RNA expression of many other genes, with 15,240 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPN-associated genes across cancer lineages are CYTH4, CSF2RB, and TLR8. Each is linked with SPN in more than 9 cancer types. Because this analysis shows association rather than direction, both SPN-to-partner and partner-to-SPN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPN→partner) and Y-score (partner→SPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYTH4 →	+1.017	+0.674	<.001	<.001	3	10
OV	CSF2RB →	+1.126	+0.918	<.001	<.001	3	10
GBM	TLR8 →	+0.940	+0.591	<.001	<.001	3	10
HNSC	NKG7 →	+1.620	+0.652	<.001	<.001	3	10
OV	BTK →	+1.062	+0.924	<.001	<.001	3	10
OV	ABI3 →	+1.072	+0.882	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,240 associations by consensus.

Exploration

SPN survival (RNA) · tumor vs normal (RNA) · all SPN data types