Across TCGA cell cohorts, SPN RNA expression is significantly associated with the go_rna of many other GO terms, with 1,757 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPN-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Viral translational termination-reinitiation. Each is linked with SPN in more than 9 cancer types. Because this analysis shows association rather than direction, both SPN-to-partner and partner-to-SPN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPN→partner) and Y-score (partner→SPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.122	+0.117	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.127	+0.117	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.095	+0.124	.001	.001	3	8
LARGE_INTESTINE	Nucleoside triphosphate biosynthetic process →	+0.053	+0.202	.004	.005	2	8
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.107	+0.114	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	ATP metabolic process →	+0.065	+0.137	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,757 associations by consensus.

Exploration

SPN survival (RNA) · tumor vs normal (RNA) · all SPN data types