Across TCGA cell cohorts, SPN mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPN-associated genes across cancer lineages are TSHB, HTR3D, and CYP4A11. Each is linked with SPN in more than 1 cancer types. Because this analysis shows association rather than direction, both SPN-to-partner and partner-to-SPN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPN→partner) and Y-score (partner→SPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSHB →	+0.123	+4.276	.004	.007	3	1
BLOOD_Leukemia	HTR3D →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CYP4A11 →	+0.042	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OR6Y1 →	+0.009	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

SPN survival (RNA) · tumor vs normal (RNA) · all SPN data types