Across TCGA patient cohorts, SPIRE2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,794 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPIRE2-associated proteins across cancer lineages are SPIRE2_S371, MSN, and P3H1. Each is linked with SPIRE2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPIRE2-to-partner and partner-to-SPIRE2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIRE2→partner) and Y-score (partner→SPIRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPIRE2_S371 →	+0.937	+0.902	<.001	<.001	3	8
GBM	MSN →	-0.416	-0.505	<.001	<.001	3	7
GBM	P3H1 →	-0.496	-0.544	.003	.003	3	6
GBM	ORC3 →	+0.344	+0.572	<.001	<.001	3	6
LSCC	RIF1 →	+0.358	+0.577	<.001	<.001	3	5
HNSC	RPRD2 →	+0.339	+0.664	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,794 associations by consensus.

Exploration

SPIRE2 survival (RNA) · tumor vs normal (RNA) · all SPIRE2 data types