Across TCGA patient cohorts, SPIRE2 protein abundance is significantly associated with the RNA expression of many other genes, with 713 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPIRE2-associated genes across cancer lineages are RPL4, CYCSP1, and HIRA. Each is linked with SPIRE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIRE2-to-partner and partner-to-SPIRE2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIRE2→partner) and Y-score (partner→SPIRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL4 →	-0.709	-0.889	.001	.005	3	2
UCEC	CYCSP1 →	-0.495	-0.285	<.001	.005	3	2
GBM	HIRA →	-0.314	-0.439	<.001	<.001	3	1
GBM	SNU13 →	-0.333	-0.343	.009	.003	3	1
GBM	BIK →	-0.443	-0.321	<.001	.006	3	1
GBM	ARFGAP1 →	-0.289	-0.333	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 713 associations by consensus.

Exploration

SPIRE2 survival (RNA) · tumor vs normal (RNA) · all SPIRE2 data types