Across TCGA patient cohorts, SPIRE2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIRE2-associated genes across cancer lineages are A-Raf_pS299, MEK1, and Shc_pY317. Each is linked with SPIRE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIRE2-to-partner and partner-to-SPIRE2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIRE2→partner) and Y-score (partner→SPIRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.195	-2.906	<.001	.001	3	2
UCEC	MEK1 →	+0.350	+2.115	.017	.017	3	2
UCEC	Shc_pY317 →	-0.162	-1.906	.007	.016	3	2
UCEC	ATM →	-0.539	-3.087	.003	<.001	3	2
UCEC	Di-Ras3 →	-0.223	-3.687	<.001	.001	3	2
COAD	PCNA →	+0.265	+3.008	.039	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

SPIRE2 survival (RNA) · tumor vs normal (RNA) · all SPIRE2 data types