Across TCGA cell cohorts, SPIRE2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPIRE2-associated genes across cancer lineages are FGF23, OR52N4, and CLLU1-AS1. Each is linked with SPIRE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIRE2-to-partner and partner-to-SPIRE2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIRE2→partner) and Y-score (partner→SPIRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FGF23 →	+0.153	+4.371	<.001	.005	3	2
URINARY_TRACT	OR52N4 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	CLLU1-AS1 →	+0.085	+4.087	<.001	.009	3	1
URINARY_TRACT	OR10G4 →	+0.012	+4.087	<.001	.009	3	1
URINARY_TRACT	CFAP97D2 →	+0.032	+4.087	<.001	.009	3	1
LARGE_INTESTINE	INSL5 →	+0.203	+3.626	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

SPIRE2 survival (RNA) · tumor vs normal (RNA) · all SPIRE2 data types