SPIRE1

Across TCGA pan-cancer cohorts, SPIRE1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SPIRE1 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPIRE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPIRE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BRCA show a favorable association.

HNSC, COAD, and SCLC are the cancer types where SPIRE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.175	0.716	<.001	39	view →
COAD	OS	Median	All	0.111	0.871	<.001	15	view →
SCLC	OS	Median	All	0.301	0.711	.018	12	view →
UCEC	DFS	Median	II,III,IV	0.915	0.438	.029	6	view →
BRCA	OS	Median	All	0.927	0.924	.046	2	view →
BLCA	OS	Median	II,III,IV	1.000	0.598	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SPIRE1–HNSC (OS)

Open the HNSC breakdown →