SPIRE1

Across TCGA patient cohorts, SPIRE1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIRE1-associated genes across cancer lineages are Cyclin-E2, p70-S6K_pT389, and ASNS. Each is linked with SPIRE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPIRE1-to-partner and partner-to-SPIRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SPIRE1-low versus SPIRE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIRE1→partner) and Y-score (partner→SPIRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.118	+1.817	.033	.015	3	3
UCEC	p70-S6K_pT389 →	-0.177	-3.584	.004	.002	3	2
UCEC	ASNS →	+0.425	+2.169	<.001	.003	3	2
UCEC	Di-Ras3 →	-0.181	-3.893	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.078	-2.195	.017	.009	3	1
UCEC	eEF2 →	+0.242	+2.459	.040	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Cyclin-E2 by SPIRE1 expression — UCEC

Explore this box plot interactively →