SPIRE1

Across TCGA cell cohorts, SPIRE1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPIRE1-associated genes across cancer lineages are MS4A4A, TAFA1, and KRTAP10-2. Each is linked with SPIRE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIRE1-to-partner and partner-to-SPIRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by SPIRE1-low versus SPIRE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIRE1→partner) and Y-score (partner→SPIRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+2.994	<.001	.006	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	ARHGAP36 →	+0.018	+3.944	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MS4A4A by SPIRE1 expression — LARGE_INTESTINE

Explore this box plot interactively →