SPINT3

Across TCGA patient cohorts, SPINT3 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINT3-associated genes across cancer lineages are RNU1-17P, LYPLA1P1, and LINC01072. Each is linked with SPINT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT3-to-partner and partner-to-SPINT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by SPINT3-low versus SPINT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT3→partner) and Y-score (partner→SPINT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-17P →	+0.590	+3.935	<.001	.003	3	2
UCEC	LYPLA1P1 →	+0.130	+5.049	<.001	.002	3	2
UCEC	LINC01072 →	+0.315	+3.488	<.001	.008	3	2
UCEC	SAMD11P1 →	+0.368	+3.656	.002	.008	3	1
UCEC	MIR5582 →	+1.106	+3.717	<.001	.003	3	1
UCEC	MIR4445 →	+0.541	+6.478	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

RNU1-17P by SPINT3 expression — UCEC

Explore this box plot interactively →