SPINT3

Across TCGA cell cohorts, SPINT3 RNA expression is significantly associated with the mutation status of many other genes, with 12 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SPINT3-associated genes across cancer lineages are ABI3, NLGN1, and ITSN2. Each is linked with SPINT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT3-to-partner and partner-to-SPINT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABI3 grouped by SPINT3-low versus SPINT3-high in PANCREAS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT3→partner) and Y-score (partner→SPINT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ABI3 →	+5.000	+0.068	.006	<.001	3	1
PANCREAS	NLGN1 →	+5.000	+0.057	.006	<.001	3	1
PANCREAS	ITSN2 →	+5.000	+0.068	.006	<.001	3	1
PANCREAS	CDK13 →	+5.000	+0.057	.006	<.001	3	1
BREAST	EIF4G2 →	+5.169	+0.603	.005	<.001	3	1
BREAST	NACAD →	+5.169	+0.441	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ABI3 by SPINT3 expression — PANCREAS

Explore this box plot interactively →