SPINT2

Across TCGA patient cohorts, SPINT2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,218 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SPINT2-associated genes across cancer lineages are PSMD8, P4HB, and AKNA. Each is linked with SPINT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPINT2-to-partner and partner-to-SPINT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINT2 versus PSMD8 in OV, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT2→partner) and Y-score (partner→SPINT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PSMD8 →	+0.910	+1.095	<.001	<.001	3	5
CCRCC	P4HB →	+0.467	+0.597	<.001	<.001	3	5
HNSC	AKNA →	-0.630	-0.427	<.001	<.001	3	4
CCRCC	CNRIP1 →	-0.633	-0.596	<.001	<.001	3	4
BRCA	RHOJ →	-0.676	-0.583	.007	.007	3	4
BRCA	AOC3 →	-1.049	-0.581	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,218 associations by consensus.

SPINT2 vs PSMD8 — OV

Explore this scatter interactively →