SPINT2

Across TCGA patient cohorts, SPINT2 mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINT2-associated genes across cancer lineages are MAP2K1, RAB11A, and SBDS. Each is linked with SPINT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT2-to-partner and partner-to-SPINT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP2K1 grouped by SPINT2-low versus SPINT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT2→partner) and Y-score (partner→SPINT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP2K1 →	+0.541	+3.491	.005	.002	3	2
UCEC	RAB11A →	+0.467	+2.700	.005	.006	3	2
UCEC	SBDS →	+0.550	+2.732	.006	.003	3	2
UCEC	POLR2M →	+0.492	+3.491	.008	.002	3	2
SKCM	RARS1 →	+0.578	+3.182	.004	.009	3	2
CESC	CCDC58P2 →	+0.096	+5.418	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

MAP2K1 by SPINT2 expression — UCEC

Explore this box plot interactively →