SPINT2

Across TCGA patient cohorts, SPINT2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINT2-associated genes across cancer lineages are PRDX1, Lck, and mTOR_pS2448. Each is linked with SPINT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT2-to-partner and partner-to-SPINT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by SPINT2-low versus SPINT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT2→partner) and Y-score (partner→SPINT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.307	+3.321	.002	.010	3	2
UCEC	Lck →	+0.395	+2.459	<.001	.020	3	1
UCEC	mTOR_pS2448 →	-0.164	-2.986	.022	.035	3	1
UCEC	p90 RSK →	+0.188	+2.179	.042	.034	3	1
UCEC	Annexin-1 →	+0.543	+3.019	.032	.019	3	1
UCEC	TIGAR →	+0.212	+3.611	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRDX1 by SPINT2 expression — UCEC

Explore this box plot interactively →