SPINT2

Across TCGA cell cohorts, SPINT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,374 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPINT2-associated GO terms across cancer lineages are Epithelial cell morphogenesis, Response to indole-3-methanol, and Establishment of epithelial cell apical/basal polarity. Each is linked with SPINT2 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPINT2-to-partner and partner-to-SPINT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cell morphogenesis grouped by SPINT2-low versus SPINT2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT2→partner) and Y-score (partner→SPINT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Epithelial cell morphogenesis →	+0.168	+3.524	<.001	.001	2	14
STOMACH	Response to indole-3-methanol →	+0.206	+3.168	<.001	<.001	3	13
LUNG_SCLC	Establishment of epithelial cell apical/basal polarity →	-0.215	-2.858	<.001	<.001	3	12
BLOOD_Myeloma	Establishment or maintenance of microtubule cytoskeleton polarity →	-0.242	-3.952	.004	.001	2	12
URINARY_TRACT	Positive regulation of iron ion transport →	+1.745	+3.184	<.001	.005	3	11
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+1.745	+3.184	<.001	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,374 associations by consensus.

Epithelial cell morphogenesis by SPINT2 expression — KIDNEY

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