SPINT2

Across TCGA cell cohorts, SPINT2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPINT2-associated genes across cancer lineages are SEMG2, MS4A3, and TBC1D21. Each is linked with SPINT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT2-to-partner and partner-to-SPINT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by SPINT2-low versus SPINT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT2→partner) and Y-score (partner→SPINT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMG2 →	+0.398	+2.878	.005	.009	3	1
LARGE_INTESTINE	MS4A3 →	+0.129	+3.584	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FAM153B →	+0.562	+3.618	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.236	+4.009	.001	<.001	3	1
LARGE_INTESTINE	PFN3 →	+0.105	+3.297	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SEMG2 by SPINT2 expression — LARGE_INTESTINE

Explore this box plot interactively →