SPINT1

Across TCGA pan-cancer cohorts, SPINT1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPINT1 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher SPINT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPINT1 expression acts as an unfavorable survival marker.

LGG, BRCA, and COAD are the cancer types where SPINT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.255	0.799	.001	12	view →
BRCA	OS	Median	All	0.110	0.578	.022	12	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	12	view →
SKCM	DFS	Median	III,IV	0.051	0.656	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPINT1–LGG (OS)

Open the LGG breakdown →