SPINT1

Across TCGA patient cohorts, SPINT1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,466 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SPINT1-associated genes across cancer lineages are GYPC, PDIA3, and RHOV. Each is linked with SPINT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPINT1-to-partner and partner-to-SPINT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINT1 versus GYPC in HNSC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT1→partner) and Y-score (partner→SPINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GYPC →	-0.708	-0.413	.001	<.001	3	7
OV	PDIA3 →	+0.548	+0.449	<.001	<.001	3	7
LSCC	RHOV →	+1.437	+0.610	<.001	<.001	3	7
LSCC	RASGRP2 →	-0.658	-0.385	<.001	.001	3	6
OV	CIB1 →	+0.701	+0.476	<.001	.002	3	6
CCRCC	PDE2A →	-0.963	-0.485	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,466 associations by consensus.

SPINT1 vs GYPC — HNSC

Explore this scatter interactively →