SPINT1

Across TCGA patient cohorts, SPINT1 mutation is significantly associated with the RNA expression of many other genes, with 929 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPINT1-associated genes across cancer lineages are RNU6-1319P, OR8G7P, and GMNN. Each is linked with SPINT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPINT1-to-partner and partner-to-SPINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1319P grouped by SPINT1-low versus SPINT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT1→partner) and Y-score (partner→SPINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1319P →	+0.547	+5.122	<.001	.004	3	3
BRCA	OR8G7P →	+0.159	+5.378	<.001	.006	3	2
SKCM	GMNN →	+0.761	+3.006	<.001	<.001	3	2
LGG	RNU1-130P →	+0.243	+7.977	<.001	.007	3	2
SKCM	RNU6-329P →	+0.072	+4.228	<.001	.004	3	2
UCEC	SUMO2P7 →	+0.362	+3.410	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 929 associations by consensus.

RNU6-1319P by SPINT1 expression — COAD

Explore this box plot interactively →