SPINT1

Across TCGA patient cohorts, SPINT1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPINT1-associated genes across cancer lineages are G6PD, ACVRL1, and LKB1. Each is linked with SPINT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT1-to-partner and partner-to-SPINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PD grouped by SPINT1-low versus SPINT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT1→partner) and Y-score (partner→SPINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	G6PD →	-0.241	-3.169	.016	.018	3	1
SKCM	ACVRL1 →	-0.143	-3.157	.031	.018	3	1
SKCM	LKB1 →	-0.129	-3.000	.020	.034	3	1
SKCM	Akt_pS473 →	+0.598	+2.459	.022	.020	3	1
SKCM	PAI-1 →	-0.811	-3.169	.010	.018	3	1
SKCM	PRAS40_pT246 →	+0.238	+2.459	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

G6PD by SPINT1 expression — SKCM

Explore this box plot interactively →