SPINT1

Across TCGA cell cohorts, SPINT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,564 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPINT1-associated GO terms across cancer lineages are Cytotoxic T cell degranulation, Negative regulation of Arp2/3 complex-mediated actin nucleation, and Bundle of His cell-Purkinje myocyte adhesion involved in cell communication. Each is linked with SPINT1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPINT1-to-partner and partner-to-SPINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytotoxic T cell degranulation grouped by SPINT1-low versus SPINT1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT1→partner) and Y-score (partner→SPINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cytotoxic T cell degranulation →	+0.317	+4.467	<.001	<.001	3	14
STOMACH	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.237	+4.212	<.001	<.001	3	14
BLOOD_Lymphoma	Bundle of His cell-Purkinje myocyte adhesion involved in cell communication →	+0.930	+1.459	.001	<.001	3	14
LUNG_SCLC	Cellular response to molecule of fungal origin →	+1.696	+3.137	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Cellular response to alcohol →	+0.144	+4.488	.001	<.001	3	13
LUNG_SCLC	Regulation of inner ear receptor cell differentiation →	+1.885	+4.623	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,564 associations by consensus.

Cytotoxic T cell degranulation by SPINT1 expression — STOMACH

Explore this box plot interactively →