SPINT1

Across TCGA cell cohorts, SPINT1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPINT1-associated genes across cancer lineages are MS4A4A, LCE1C, and GP9. Each is linked with SPINT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT1-to-partner and partner-to-SPINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by SPINT1-low versus SPINT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT1→partner) and Y-score (partner→SPINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.188	+3.678	<.001	.009	3	1
LARGE_INTESTINE	LCE1C →	+0.062	+3.684	.004	.006	3	1
CNS	GP9 →	+0.019	+4.754	<.001	.005	3	1
BLOOD_Leukemia	GUCA1C →	+0.019	+3.969	<.001	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.028	+3.475	<.001	.006	3	1
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MS4A4A by SPINT1 expression — LARGE_INTESTINE

Explore this box plot interactively →