Across TCGA patient cohorts, SPINK9 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK9-associated genes across cancer lineages are RBMY3AP, RNU4-69P, and RPS17P17. Each is linked with SPINK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK9-to-partner and partner-to-SPINK9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK9→partner) and Y-score (partner→SPINK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RBMY3AP →	+0.858	+4.513	<.001	.009	3	1
UCEC	RNU4-69P →	+0.502	+4.335	<.001	.007	3	1
UCEC	RPS17P17 →	+0.371	+4.224	<.001	.001	3	1
UCEC	LINC01820 →	+0.280	+4.756	<.001	<.001	3	1
UCEC	RPL32P28 →	+0.410	+4.315	<.001	.001	3	1
UCEC	ZMYND10-AS1 →	+0.424	+3.239	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

SPINK9 survival (RNA) · tumor vs normal (RNA) · all SPINK9 data types