SPINK8

Across TCGA patient cohorts, SPINK8 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,882 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPINK8-associated proteins across cancer lineages are SNX1, SLC9A1, and SRSF11. Each is linked with SPINK8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPINK8-to-partner and partner-to-SPINK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK8 versus SNX1 in HNSC, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK8→partner) and Y-score (partner→SPINK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNX1 →	-0.170	-0.416	<.001	<.001	3	3
BRCA	SLC9A1 →	+0.289	+2.150	.002	<.001	3	2
BRCA	SRSF11 →	-0.240	-2.402	<.001	<.001	3	2
BRCA	TACC1 →	+0.548	+2.989	<.001	<.001	3	2
BRCA	TAMALIN_S94 →	+0.476	+2.170	.003	.002	3	2
BRCA	TARS2 →	-0.249	-1.629	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,882 associations by consensus.

SPINK8 vs SNX1 — HNSC

Explore this scatter interactively →