SPINK8

Across TCGA patient cohorts, SPINK8 protein abundance is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPINK8-associated genes across cancer lineages are PCDHB3, GDA, and OR1J1. Each is linked with SPINK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK8-to-partner and partner-to-SPINK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK8 versus PCDHB3 in BRCA, with a Pearson correlation of 0.96.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK8→partner) and Y-score (partner→SPINK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCDHB3 →	+3.635	+0.769	.002	.004	3	1
BRCA	GDA →	+0.040	+0.699	.007	<.001	3	1
BRCA	OR1J1 →	+0.537	+0.796	.003	.003	3	1
BRCA	UNC93B2 →	+0.229	+0.569	<.001	.002	3	1
BRCA	ATP2B2 →	+0.282	+0.796	.006	.003	3	1
BRCA	C16orf78 →	+0.206	+0.569	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

SPINK8 vs PCDHB3 — BRCA

Explore this scatter interactively →