SPINK8

Across TCGA patient cohorts, SPINK8 mutation is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SPINK8-associated genes across cancer lineages are RNU6-1264P, MIR100, and TRIM49C. Each is linked with SPINK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK8-to-partner and partner-to-SPINK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1264P grouped by SPINK8-low versus SPINK8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK8→partner) and Y-score (partner→SPINK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1264P →	+0.214	+4.245	<.001	.006	3	2
COAD	MIR100 →	+1.988	+7.741	<.001	.009	3	2
COAD	TRIM49C →	+0.354	+7.741	<.001	.009	3	2
COAD	RN7SKP46 →	+0.439	+7.741	<.001	.009	3	2
UCEC	PCBP1-AS1 →	+0.553	+3.255	<.001	.009	3	1
UCEC	AQP7P2 →	+0.246	+2.595	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

RNU6-1264P by SPINK8 expression — UCEC

Explore this box plot interactively →