SPINK8

Across TCGA patient cohorts, SPINK8 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK8-associated genes across cancer lineages are MEK1, Tuberin, and Caspase-7-cleavedD198. Each is linked with SPINK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK8-to-partner and partner-to-SPINK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SPINK8-low versus SPINK8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK8→partner) and Y-score (partner→SPINK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.511	+3.000	.015	.036	3	1
UCEC	Tuberin →	+0.448	+3.000	.003	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.773	+2.827	.024	.035	3	1
UCEC	C-Raf →	+0.172	+3.000	.037	.037	3	1
UCEC	GATA6 →	-0.194	-3.000	.029	.035	2	1
UCEC	PDCD4 →	-0.799	-3.000	.003	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MEK1 by SPINK8 expression — UCEC

Explore this box plot interactively →