SPINK7

Across TCGA patient cohorts, SPINK7 mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK7-associated genes across cancer lineages are SNRPGP8, TSPY8, and TSPY12P. Each is linked with SPINK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK7-to-partner and partner-to-SPINK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP8 grouped by SPINK7-low versus SPINK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK7→partner) and Y-score (partner→SPINK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP8 →	+0.137	+3.352	.001	.004	3	2
UCEC	TSPY8 →	+0.010	+5.744	<.001	<.001	3	2
SKCM	TSPY12P →	+0.044	+4.634	<.001	.003	3	2
UCEC	PRKY →	+0.119	+3.005	<.001	.004	3	2
UCEC	MYO19 →	+0.562	+3.459	.005	.005	3	1
UCEC	H2BC10 →	+0.692	+3.459	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

SNRPGP8 by SPINK7 expression — UCEC

Explore this box plot interactively →