SPINK6

Across TCGA patient cohorts, SPINK6 protein abundance is significantly associated with the RNA expression of many other genes, with 826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK6-associated genes across cancer lineages are SPINK7, NIP7P2, and SPATA5. Each is linked with SPINK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK6-to-partner and partner-to-SPINK6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK6 versus SPINK7 in HNSC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK6→partner) and Y-score (partner→SPINK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPINK7 →	+3.655	+3.312	.001	.001	3	2
HNSC	NIP7P2 →	-0.835	-2.915	.005	.001	3	2
LSCC	SPATA5 →	-0.533	-1.183	.007	.006	3	1
LSCC	DAAM2 →	-1.103	-1.193	.008	.006	3	1
LSCC	PTPRD →	-1.443	-0.863	<.001	.003	3	1
LSCC	GP2 →	+0.060	+1.504	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 826 associations by consensus.

SPINK6 vs SPINK7 — HNSC

Explore this scatter interactively →