SPINK4

Across TCGA cell cohorts, SPINK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,899 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPINK4-associated GO terms across cancer lineages are Regulation of amacrine cell differentiation, Response to prostaglandin D, and Cellular response to prostaglandin D stimulus. Each is linked with SPINK4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPINK4-to-partner and partner-to-SPINK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of amacrine cell differentiation grouped by SPINK4-low versus SPINK4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK4→partner) and Y-score (partner→SPINK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of amacrine cell differentiation →	-0.872	-2.695	.005	.001	3	6
LARGE_INTESTINE	Response to prostaglandin D →	+0.735	+3.273	<.001	<.001	3	6
LARGE_INTESTINE	Cellular response to prostaglandin D stimulus →	+0.735	+3.273	<.001	<.001	3	6
LARGE_INTESTINE	Terpenoid catabolic process →	+1.182	+3.838	<.001	<.001	3	5
STOMACH	Mitochondrial transmembrane transport →	+0.102	+2.991	<.001	.003	2	6
URINARY_TRACT	Cellular oxidant detoxification →	+0.073	+2.658	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,899 associations by consensus.

Regulation of amacrine cell differentiation by SPINK4 expression — STOMACH

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