Across TCGA pan-cancer cohorts, SPINK13 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPINK13 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SPINK13 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPINK13 expression acts as an unfavorable survival marker, although some lineages such as BRCA show a favorable association.

COAD, UCEC, and BRCA are the cancer types where SPINK13 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.082	0.871	<.001	48	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BRCA	OS	Median	All	0.927	0.924	.047	2	view →
SKCM	OS	Median	All	0.519	0.790	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SPINK13 tumor-vs-normal RNA expression · all SPINK13 data types