Across TCGA patient cohorts, SPINK13 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK13-associated genes across cancer lineages are EGFR_pY1068, Gab2, and JNK2. Each is linked with SPINK13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK13-to-partner and partner-to-SPINK13 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK13→partner) and Y-score (partner→SPINK13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.253	-2.584	.021	.010	3	1
UCEC	Gab2 →	+0.410	+2.115	.008	.019	3	1
UCEC	JNK2 →	+0.259	+3.026	.002	.018	3	1
UCEC	NDRG1_pT346 →	-0.442	-3.000	.039	.036	3	1
UCEC	P-Cadherin →	-0.151	-2.999	.016	.035	3	1
UCEC	Shc_pY317 →	-0.209	-2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

SPINK13 survival (RNA) · tumor vs normal (RNA) · all SPINK13 data types