SPIN4-AS1

Across TCGA pan-cancer cohorts, SPIN4-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SPIN4-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPIN4-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPIN4-AS1 expression acts as an unfavorable survival marker, although some lineages such as ACC and BRCA show a favorable association.

KIRC, ACC, and BRCA are the cancer types where SPIN4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.497	0.732	<.001	110	view →
ACC	DFS	Median	III,IV	0.577	0.117	.003	42	view →
BRCA	DFS	Median	III,IV	0.933	0.822	.013	36	view →
UCEC	OS	Tertile	IV	0.194	0.546	.018	36	view →
READ	OS	Tertile	IV	0.555	0.893	.001	30	view →
THCA	OS	Median	III,IV	0.886	0.978	.004	17	view →
LGG	DFS	Median	All	0.793	0.870	.003	13	view →
TGCT	DFS	Tertile	All	0.934	0.760	.036	12	view →
KIRP	DFS	Tertile	All	0.946	0.653	.015	12	view →
CHOL	OS	Tertile	All	1.000	0.389	.047	9	view →
LIHC	DFS	Tertile	III,IV	0.791	0.289	.042	9	view →
UVM	DFS	Tertile	III,IV	0.283	0.590	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SPIN4-AS1–KIRC (DFS)

Open the KIRC breakdown →