SPIN1

Across TCGA pan-cancer cohorts, SPIN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SPIN1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPIN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SPIN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where SPIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.632	0.913	.001	49	view →
CCRCC	OS	Median	All	0.934	0.740	.005	20	view →
GBM	DFS	Tertile	All	0.462	0.276	.010	12	view →
PDAC	OS	Median	II,III,IV	0.279	0.496	.015	9	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.039	2	view →
LUAD	DFS	Median	III,IV	0.908	0.605	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SPIN1–HNSC (OS)

Open the HNSC breakdown →