SPIN1

Across TCGA patient cohorts, SPIN1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIN1-associated genes across cancer lineages are MSH2, 14-3-3_beta, and A-Raf_pS299. Each is linked with SPIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIN1-to-partner and partner-to-SPIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by SPIN1-low versus SPIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIN1→partner) and Y-score (partner→SPIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.284	-2.781	.001	.003	3	2
UCEC	14-3-3_beta →	-0.123	-3.308	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.193	-2.807	<.001	.003	3	1
UCEC	ERK2 →	+0.188	+1.765	.009	.014	3	1
UCEC	GAPDH →	+0.423	+2.000	.035	.030	3	1
UCEC	GATA6 →	-0.177	-2.700	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

MSH2 by SPIN1 expression — UCEC

Explore this box plot interactively →