SPIN1

Across TCGA cell cohorts, SPIN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,486 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPIN1-associated GO terms across cancer lineages are Protein monoubiquitination, Regulation of maintenance of sister chromatid cohesion, and Regulation of maintenance of mitotic sister chromatid cohesion. Each is linked with SPIN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SPIN1-to-partner and partner-to-SPIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein monoubiquitination grouped by SPIN1-low versus SPIN1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIN1→partner) and Y-score (partner→SPIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein monoubiquitination →	+0.081	+0.920	.005	.002	3	17
LUNG_SCLC	Regulation of maintenance of sister chromatid cohesion →	+0.097	+0.670	.004	<.001	3	16
LUNG_SCLC	Regulation of maintenance of mitotic sister chromatid cohesion →	+0.097	+0.670	.004	<.001	3	16
PANCREAS	Immunoglobulin heavy chain V-D-J recombination →	+0.184	+0.747	.002	<.001	3	16
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.066	+1.178	<.001	.001	3	16
BLOOD_Lymphoma	Nucleic acid transport →	+0.086	+1.144	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,486 associations by consensus.

Protein monoubiquitination by SPIN1 expression — LIVER

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