SPIDR

Across TCGA pan-cancer cohorts, SPIDR mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPIDR’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SPIDR mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SPIDR is over-expressed in tumor.

LUAD, PDAC, and LSCC are the cancer types where SPIDR tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPIDR mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.468	<.001	6	view →
PDAC	Female	II,III,IV	+1.192	<.001	5	view →
LSCC	All	All	+0.426	<.001	5	view →
HNSC	All	All	+0.249	.019	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPIDR–LUAD

Open the LUAD breakdown →