SPICE1

Across TCGA pan-cancer cohorts, SPICE1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SPICE1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SPICE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPICE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

THYM, UCEC, and BLCA are the cancer types where SPICE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	1.000	0.616	.003	36	view →
BLCA	OS	Median	All	0.063	0.688	<.001	30	view →
LIHC	OS	Median	All	0.181	0.709	<.001	18	view →
SCLC	OS	Median	III,IV	0.082	0.639	<.001	12	view →
STAD	DFS	Median	II,III,IV	0.089	0.641	<.001	12	view →
LUAD	DFS	Median	All	0.397	0.773	<.001	12	view →
SKCM	DFS	Median	All	0.245	0.640	.016	6	view →
COAD	DFS	Median	II,III,IV	1.000	0.421	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SPICE1–THYM (OS)

Open the THYM breakdown →