SPICE1

Across TCGA patient cohorts, SPICE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,786 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SPICE1-associated proteins across cancer lineages are HDAC2, ZNF148, and AGO1. Each is linked with SPICE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPICE1-to-partner and partner-to-SPICE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPICE1 versus HDAC2 in GBM, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPICE1→partner) and Y-score (partner→SPICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HDAC2 →	+0.291	+0.468	.002	<.001	3	5
GBM	ZNF148 →	+0.236	+0.400	<.001	<.001	3	5
HNSC	AGO1 →	+0.239	+0.516	<.001	.002	3	5
BRCA	IFT122 →	+0.379	+0.503	<.001	<.001	3	4
PDAC	NIT2 →	+0.326	+0.292	.002	.002	3	4
PDAC	RUVBL1 →	+0.276	+0.463	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,786 associations by consensus.

SPICE1 vs HDAC2 — GBM

Explore this scatter interactively →