SPICE1

Across TCGA patient cohorts, SPICE1 mutation is significantly associated with the RNA expression of many other genes, with 2,767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPICE1-associated genes across cancer lineages are DSN1, MIR4632, and ANOS2P. Each is linked with SPICE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPICE1-to-partner and partner-to-SPICE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSN1 grouped by SPICE1-low versus SPICE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPICE1→partner) and Y-score (partner→SPICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DSN1 →	+0.439	+2.095	.006	.003	3	3
BLCA	MIR4632 →	+0.751	+5.064	<.001	.001	3	2
CESC	ANOS2P →	+0.022	+5.539	<.001	.004	3	2
LIHC	CCER1 →	+0.066	+4.771	<.001	.001	3	2
BLCA	SCGB1D4 →	+0.170	+4.497	<.001	.009	3	2
LIHC	RNA5SP457 →	+0.242	+4.564	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,767 associations by consensus.

DSN1 by SPICE1 expression — UCEC

Explore this box plot interactively →