SPICE1

Across TCGA patient cohorts, SPICE1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPICE1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, FoxM1, and Rad50. Each is linked with SPICE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPICE1-to-partner and partner-to-SPICE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SPICE1-low versus SPICE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPICE1→partner) and Y-score (partner→SPICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p38-MAPK_pT180_Y182 →	-0.433	-3.459	.012	.005	3	2
UCEC	FoxM1 →	+0.297	+2.392	.001	<.001	3	2
UCEC	Rad50 →	-0.281	-2.000	.001	.003	3	2
UCEC	RAD51 →	+0.118	+2.222	.016	.010	3	2
UCEC	Annexin-1 →	+0.512	+2.019	.005	.017	3	2
UCEC	ASNS →	+0.356	+1.700	.005	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p38-MAPK_pT180_Y182 by SPICE1 expression — SKCM

Explore this box plot interactively →