SPICE1

Across TCGA cell cohorts, SPICE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,693 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPICE1-associated GO terms across cancer lineages are Regulation of centriole replication, Regulation of organelle assembly, and Positive regulation of mRNA metabolic process. Each is linked with SPICE1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SPICE1-to-partner and partner-to-SPICE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centriole replication grouped by SPICE1-low versus SPICE1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPICE1→partner) and Y-score (partner→SPICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of centriole replication →	+0.110	+0.992	<.001	<.001	3	17
STOMACH	Regulation of organelle assembly →	+0.063	+0.968	.007	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mRNA metabolic process →	+0.062	+0.900	.004	.001	3	12
OVARY	Positive regulation of cytoplasmic translation →	+0.125	+0.978	<.001	<.001	3	12
OVARY	RNA localization →	+0.071	+0.833	<.001	<.001	3	11
BLOOD_Lymphoma	mRNA destabilization →	+0.059	+0.716	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,693 associations by consensus.

Regulation of centriole replication by SPICE1 expression — LUNG_SCLC

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