SPICE1

Across TCGA cell cohorts, SPICE1 protein abundance is significantly associated with the RNA expression of many other genes, with 526 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible SPICE1-associated genes across cancer lineages are CRLF1, SYTL2, and ROPN1L. Each is linked with SPICE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPICE1-to-partner and partner-to-SPICE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPICE1 versus CRLF1 in LARGE_INTESTINE, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPICE1→partner) and Y-score (partner→SPICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRLF1 →	+1.599	+1.903	.004	.006	2	4
BREAST	SYTL2 →	-4.705	-0.925	.003	.004	2	3
BREAST	ROPN1L →	+0.279	+0.925	<.001	.004	3	2
BREAST	CFAP46 →	+0.956	+1.153	.001	.002	2	3
BREAST	PLSCR3 →	+0.995	+0.925	<.001	.004	3	2
OESOPHAGUS	RIBC2 →	+2.347	+1.109	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 526 associations by consensus.

SPICE1 vs CRLF1 — LARGE_INTESTINE

Explore this scatter interactively →