SPICE1

Across TCGA cell cohorts, SPICE1 protein abundance is significantly associated with the go_rna of many other GO terms, with 327 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPICE1-associated GO terms across cancer lineages are Positive regulation of type 2 mitophagy, Nuclear mRNA surveillance, and Mesenchymal to epithelial transition. Each is linked with SPICE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPICE1-to-partner and partner-to-SPICE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of type 2 mitophagy grouped by SPICE1-low versus SPICE1-high in OESOPHAGUS.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPICE1→partner) and Y-score (partner→SPICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of type 2 mitophagy →	+0.109	+1.109	<.001	.009	3	3
LARGE_INTESTINE	Nuclear mRNA surveillance →	+0.045	+1.515	<.001	.008	2	3
BREAST	Mesenchymal to epithelial transition →	-0.284	-0.925	.008	.004	2	3
OESOPHAGUS	Nucleoside salvage →	+0.165	+1.108	.005	.009	3	2
BREAST	Neuropeptide catabolic process →	-0.242	-0.925	.005	.004	3	2
BREAST	Negative regulation of polyamine transmembrane transport →	+0.222	+1.153	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

Positive regulation of type 2 mitophagy by SPICE1 expression — OESOPHAGUS

Explore this box plot interactively →