SPIB

Across TCGA patient cohorts, SPIB mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIB-associated genes across cancer lineages are Notch1, eEF2, and GATA6. Each is linked with SPIB in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIB-to-partner and partner-to-SPIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SPIB-low versus SPIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIB→partner) and Y-score (partner→SPIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.185	+3.000	.022	.037	3	2
UCEC	eEF2 →	+0.465	+3.000	.024	.037	3	1
UCEC	GATA6 →	-0.246	-2.992	.005	.036	3	1
UCEC	PREX1 →	-0.411	-2.999	.009	.035	3	1
UCEC	Ku80 →	+0.289	+3.013	.034	.019	2	1
UCEC	Mre11 →	-0.130	-3.000	.008	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by SPIB expression — UCEC

Explore this box plot interactively →