SPIB

Across TCGA cell cohorts, SPIB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,034 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPIB-associated GO terms across cancer lineages are Cell cycle G1/S phase transition, Regulation of double-strand break repair via homologous recombination, and Regulation of DNA recombination. Each is linked with SPIB in more than 8 cancer types. Because this analysis shows association rather than direction, both SPIB-to-partner and partner-to-SPIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle G1/S phase transition grouped by SPIB-low versus SPIB-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIB→partner) and Y-score (partner→SPIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cell cycle G1/S phase transition →	+0.106	+0.861	<.001	<.001	3	9
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.080	+0.508	<.001	<.001	3	9
SOFT_TISSUE	Regulation of DNA recombination →	+0.060	+0.516	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of double-strand break repair via homologous recombination →	+0.117	+0.816	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of DNA recombination →	+0.075	+0.568	<.001	.001	3	8
SOFT_TISSUE	Regulation of DNA repair →	+0.059	+0.558	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,034 associations by consensus.

Cell cycle G1/S phase transition by SPIB expression — SOFT_TISSUE

Explore this box plot interactively →