SPIB

Across TCGA cell cohorts, SPIB protein abundance is significantly associated with the drug of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPIB-associated genes across cancer lineages are Dabrafenib, Shikonin, and 765771. Each is linked with SPIB in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIB-to-partner and partner-to-SPIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dabrafenib grouped by SPIB-low versus SPIB-high in BLOOD_Lymphoma.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIB→partner) and Y-score (partner→SPIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Dabrafenib →	-0.615	-1.384	.047	.008	3	1
BLOOD_Lymphoma	Shikonin →	+0.696	+1.420	.042	.015	3	1
BLOOD_Lymphoma	765771 →	-0.778	-1.272	.001	.031	3	1
BLOOD_Lymphoma	THZ-2-49 →	+0.870	+1.843	.002	.027	3	1
BLOOD_Lymphoma	AZ20 →	+0.714	+1.516	.009	.009	2	1
BLOOD_Lymphoma	CPI-637 →	-0.845	-1.345	.045	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Dabrafenib by SPIB expression — BLOOD_Lymphoma

Explore this box plot interactively →